Basal Fiber Inheritance: Time-Lapse of Drosophila Neuroblast & GMC Divisions 🔬🧠

https://www.youtube.com/watch?v=mlEreajw8vk

Original video: https://youtu.be/mlEreajw8vk

Published on: 06 October 2020

Watch the intricate cellular dynamics of neural stem cell reactivation in this two-part time-lapse study of the Drosophila larval brain. Using a specialized immobilisation technique, this footage captures the precise inheritance of basal fibers structures characteristic of quiescent neuroblasts; during the first divisions after reactivation.

Contrary to models in other organisms where the stem cell typically retains the fiber, these recordings reveal that in Drosophila, the fiber is asymmetrically inherited by the daughter progeny. This discovery suggests a potential mechanism for the rapid development of neurites in fast-developing organisms.

Keywords:

Basal Fiber Inheritance, Neuroblast Reactivation, Ganglion Mother Cell, Drosophila Larva, Cell Biology, Asymmetric Division, Neural Stem Cells, 2-Photon Imaging, VNC, Frontiers in Cell and Developmental Biology.

Citation:

Bostock MP, Prasad AR, Chaouni R, Yuen AC, Sousa-Nunes R, Amoyel M and Fernandes VM (2020) An Immobilization Technique for Long-Term Time-Lapse Imaging of Explanted Drosophila Tissues. Front. Cell Dev. Biol. 8:590094. doi: 10.3389/fcell.2020.590094

Attribution 4.0 International — CC BY 4.0 - Creative Commons